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KMID : 1123920140280010029
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 1 p.29 ~ p.34
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Inhibitory Effect on RANKL-Induced Osteoclast Differentiation by Water Extract of Zizyphus Jujuba Mill
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Yoon Kang-Hue
Back Jong-Min
Kim Ju-Young
Kwack Seong-Cheoul
Cheon Yoon-Hee
Jeon Byung-Hoon
Lee Chang-Hun
Choi Min-Kyu
Oh Jae-Min
Lee Myeung-Su
Kim Jeong-Joong
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Abstract
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Bone homeostasis is maintained by balance between bone resorbing-osteoclasts and bone forming-osteoblasts. Excessive osteoclastic bone resorption plays a critical role in bone destruction in pathological bone diseases such as osteoporosis, rheumatoid arthritis, and periodontal disease. Many compounds derived from natural products have pharmacological applications and have therapeutic value for treating or preventing several bone diseases characterized by excessive bone resorption. To discover new compounds that can act as anti-resorptive agents, we screened for natural compounds that regulate osteclast differentiation, and found that water extract of Ziziphus Jujuba Mill (WEZJ) has inhibitory effects on osteoclast differentiation. In this study, WEZJ clearly inhibits the osteoclast differentiation in the presence of receptor activator of nuclear factor kB (RANKL), macrophage colony-stimulating factor (M-CSF) without cytoxicity by blocking activation of nuclear factor of activated T cells (NFAT)c1, and c-Fos. In signaling pathway, the phosphorylation of Akt, p38, c-Jun N-terminal kinases (JNK), extracellular signal-regulated kinases (ERK) and the expression of osteoclast-associated receptor (OSCAR), tartrate-resistant acid phosphates (TRAP), Integrin av, Integrin b3, Cathepsin K are suppressed, too. These result suggest that WEZJ may have therapeutic value for treating or preventing several bone diseases characterized by excessive bone destruction.
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KEYWORD
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Zizyphus Jujuba Mill, Osteoclast, Differentiation, Bone resorption, Osteoporosis Therapy
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